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The Impact of Radiotherapy on Oligometastatic Cancer
Sponsor: Institut Investigacio Sanitaria Pere Virgili
Summary
Metastases represent the most threatening challenge in cancer. One of the management strategies for patients with Oligometastatic Cancer (OC) is Stereotactic ABlative Radiotherapy (SABR). However, there are few studies, and there is no defined clinical standard, nor are the radiobiological mechanisms that contribute to treatment response well understood. The focus should be on generating evidence to guide the personalization of radiotherapy beyond solely technological and anatomical precision. This could be achieved by recollecting clinical and biological data from patients that undergo this treatment and analyzing them to ultimately predict, with the help of artificial intelligence, which patients will be the most beneficiary and improve their survival rate.
Official title: Stereotactic ABlative Radiotherapy (SABR) in Oligometastatic Cancer (OC): a Radiomics, Multi-omics, and Machine Learning Approach to Clinical Decision-making. the OC-SABR Multicentric Project
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
2000
Start Date
2022-12-01
Completion Date
2037-12-31
Last Updated
2024-11-18
Healthy Volunteers
No
Conditions
Interventions
To propose a diagnostic test to determine the viability of Stereotactic ABlative Radiotherapy (SABR).
Analyze clinical data, medical images and molecular circulating features to propose which variables serve to select the patients that will achieve complete response after SABR.
To propose a diagnostic test to determine the effectiveness of SABR.
Collect blood samples at five different time points before and after treatment and analyze circulating tumoral DNA, medical images, and metabolites to monitor the effect of SABR and its effectiveness.
To propose a diagnostic test for Oligometastatic Cancer (OC).
Analyze circulating tumoral DNA and metabolites from blood samples in search of the profile of OC.
Locations (21)
Complejo Hospitalario Universitario Albacete
Albacete, Albacete, Spain
Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Barcelona, Barcelona, Spain
Hospital Universitari Vall d'Hebron
Barcelona, Barcelona, Spain
Institut Català d'Oncologia
Barcelona, Barcelona, Spain
Hospital Universitario Virgen de las Nieves
Granada, Granada, Spain
Hospital Universitari Arnau de Vilanova
Lleida, Lleida, Spain
Hospital de La Luz
Madrid, Madrid, Spain
Hospital Ruber Internacional
Madrid, Madrid, Spain
Hospital Universitario HM Sanchinarro
Madrid, Madrid, Spain
Hospital Universitario Quirónsalud
Madrid, Madrid, Spain
Hospital Universitario Rey Juan Carlos
Madrid, Madrid, Spain
Hospital Universitario Virgen Macarena
Seville, Sevilla, Spain
Hospital Universitari Sant Joan de Reus
Reus, Tarragona, Spain
Hospital Clínico Universitario de Valencia
Valencia, Valencia, Spain
Hospital General Univesitario de Valencia
Valencia, Valencia, Spain
Hospital Universitari Miguel Servet
Zaragoza, Zaragoza, Spain
Hospital del Mar
Barcelona, Spain
Hospital Provincial de Castellón
Castellon, Spain
Institut Català d'Oncologia
Girona, Spain
Hospital Universitario Ramón y Cajal
Madrid, Spain
Hospital de Terrassa
Terrassa, Spain