Clinical Research Directory

Inclusion Criteria: X-ALD group： * Meet the diagnostic criteria of X-ALD and supported by the results of genetic and very long chain fatty acid (VLCFA) test; * Age: 6 - 70 years old; * Able to communicate normally, and complete the test of scale as instructed (confirmed by the field test of scale); * Sign the informed consent. Carrier-control group: Healthy people who have no significant difference in age, sex and education comparing with the X-ALD group, volunteer to participate in this study, could complete the test of scale as instructed, and meet the following criteria: * Eligible for asymptomatic carriers in genetic tests (preference of patient's mother and close relatives); * Age: 6 - 70 years old, able to complete the test of scale as instructed (confirmed by the field test of scale); * No history of psychiatric diseases. Exclusion Criteria: * Other hereditary diseases; * Other severe central nervous diseases; * History of surgery of brain or eye; * Psychiatric and psychological diseases, such as anxiety and depression; * Metal foreign body or prosthesis in the human body (such as pacemaker and insulin pump), claustrophobia, and other MRI contraindications; * History of surgery associated with gastrointestinal tract; * No informed consent; * Unable to tolerate MRI or eye related tests.