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Possible Diagnostic Protein Markers in Schistosoma Related Bladder Diseases.
Sponsor: Assiut University
Summary
Schistosomiasis is the second most common parasitic infection affecting humans, endemic in the Middle East, especially Egypt (1), and in 42 African countries (2). There are 5 main species infecting humans: S. mansoni, S. haematobium, S. japonicum, S. intercalatum, and S. mekongi. S. haematobium is responsible for chronic urogenital infections that may cause serious complications (3). Urinary schistosomiasis is mostly borne in rural and agricultural communities, according to WHO (4)
Key Details
Gender
All
Age Range
30 Years - Any
Study Type
OBSERVATIONAL
Enrollment
120
Start Date
2023-10-01
Completion Date
2027-10-30
Last Updated
2023-07-12
Healthy Volunteers
Yes
Conditions
Interventions
Immunohistochemistry staining,
Tissue samples: * Histopathological examination: Hematoxylin and Eosin slides will be prepared and examined. * The only dependable criterion for the diagnosis of bilharzial infestation is the microscopic detection of Bilharzia ova in pathological sections. * Pathology (cystitis- cancer and its grade staging will be reported in accordance with the 2022 World Health Organization Classification of Tumors of the Urinary System (17). * To quantify levels of Nuclear factor kappa B and protein kinase c α: * Immunohistochemistry according to the manufacturer's instructions.
microscopic examination of urine
Urine samples: * Mic roscopic examination (detection of S. haematobium egg - egg counting) * Detection of HSP 70 Measurements: indirect ELISA will be used to quantify HSP concentrations in urine.
Locations (1)
Assiut University Hospital
Asyut, Egypt