Clinical Research Directory

Inclusion Criteria: 1. Adults (aged ≥18); 2. Diagnosed with liver cancer based on pathological findings or imaging findings in the medical record; 3. The severity level of depression and anxiety: Depression \> 7 using HAD-D, or Anxiety \> 7 using HAD-A (Hospital Anxiety and Depression Scale, HADS; HAD-D, Hospital Depression Scale; HAD-A, Hospital Anxiety Scale). Exclusion Criteria: 1. Patients who are taking part in another psychological intervention clinical trial or consented to receive another psychotherapy, suffered from aphasia and other communication difficulties will be excluded from the study 2. Patients with active immunological diseases, such as autoimmune diseases, and inflammatory diseases. 3. Patients accepting hormone therapy or taking long-term antibiotic drugs. 4. Patients who lack the basic ability of understanding and expression and are incompetent in giving consent.