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Piperacillin/Tazobactam Versus ceftriAxone and Metronidazole for Children With Perforated Appendicitis (ALPACA)
Sponsor: McMaster Children's Hospital
Summary
This study is an internal pilot for a multicenter, blinded randomized controlled trial. The purpose of the multicenter trial is to determine whether post-operative piperacillin/tazobactam is more effective than ceftriaxone and metronidazole for children treated with laparoscopic appendectomy for perforated appendicitis. We plan to conduct an internal pilot study to determine whether a blinded multicenter randomized controlled trial is feasible.
Official title: Assessing the Longitudinal Outcomes of Piperacillin/Tazobactam Versus ceftriAxone and Metronidazole for Children With Perforated Appendicitis (ALPACA): a Randomized Controlled Trial
Key Details
Gender
All
Age Range
Any - 18 Years
Study Type
INTERVENTIONAL
Enrollment
16
Start Date
2024-09-09
Completion Date
2025-10-20
Last Updated
2026-07-07
Healthy Volunteers
No
Conditions
Interventions
Piperacillin/tazobactam
Post-operative piperacillin/tazobactam 100 mg/kg IV q8h (to a maximum of 4.5 g IV q8h)
Normal saline
Post-operative normal saline 50 mL once daily
CefTRIAXone Injection
Post-operative ceftriaxone 50 mg/kg IV once daily (to a maximum of 2 g IV once daily)
Metronidazole Injection
Post-operative metronidazole 10 mg/kg IV q8h (to a maximum of 500 mg IV q8h)
Locations (1)
McMaster Children's Hospital
Hamilton, Ontario, Canada