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RECRUITING
NCT05946798
EARLY_PHASE1
Role of NADPH Oxidase in Microvascular Dysfunction Following GDM
Sponsor: Anna Stanhewicz, PhD
View on ClinicalTrials.gov
Summary
The purpose of this investigation is to examine NADPH oxidase as a source of reactive oxygen species contributing to aberrant microvascular function in otherwise healthy women with a history of GDM.
Key Details
Gender
FEMALE
Age Range
18 Years - 50 Years
Study Type
INTERVENTIONAL
Enrollment
40
Start Date
2023-08-30
Completion Date
2028-06-01
Last Updated
2025-05-13
Healthy Volunteers
Yes
Interventions
DRUG
Acetylcholine
acetylcholine is perfused at 10 ascending concentrations (10\^-10M - 10\^-1 M) for 5 minutes each
DRUG
Insulin aspart
insulin aspart is perfused at 5 ascending concentrations (10\^-8M - 10\^-4 M) for 10 minutes each
Locations (1)
University of Iowa
Iowa City, Iowa, United States