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RECRUITING
NCT05946798
EARLY_PHASE1

Role of NADPH Oxidase in Microvascular Dysfunction Following GDM

Sponsor: Anna Stanhewicz, PhD

View on ClinicalTrials.gov

Summary

The purpose of this investigation is to examine NADPH oxidase as a source of reactive oxygen species contributing to aberrant microvascular function in otherwise healthy women with a history of GDM.

Key Details

Gender

FEMALE

Age Range

18 Years - 50 Years

Study Type

INTERVENTIONAL

Enrollment

40

Start Date

2023-08-30

Completion Date

2028-06-01

Last Updated

2025-05-13

Healthy Volunteers

Yes

Interventions

DRUG

Acetylcholine

acetylcholine is perfused at 10 ascending concentrations (10\^-10M - 10\^-1 M) for 5 minutes each

DRUG

Insulin aspart

insulin aspart is perfused at 5 ascending concentrations (10\^-8M - 10\^-4 M) for 10 minutes each

Locations (1)

University of Iowa

Iowa City, Iowa, United States