Clinical Research Directory

Inclusion Criteria: * 2 months of age (60\~89 days), 3 months of age (90\~119 days), willing to provide identification documents * The legal guardian or delegate has given informed consent, voluntarily signed the informed consent form, and can comply with the requirements of the clinical study protocol Exclusion Criteria: * Infants 2 months of age who have received a vaccine containing the components of diphtheria, IPV, Hib, or 13-valent pneumococcal polysaccharide conjugate vaccine * Infants 3 months of age who have received vaccines containing diphtheria, Hib, or 13-valent pneumococcal polysaccharide conjugate vaccine or group A, group C meningococcal conjugate vaccine * 3-month-old infant vaccinated with IPV * Premature birth (delivery before the 37th week of gestation), low birth weight (birth weight \<2500g) for 2-month-old (60-89 days) and 3-month-old (90-119 days) infants * History of abnormal labor, asphyxia, and neurological damage * Those who have suffered from pertussis, diphtheria or tetanus * Individuals who have had household contact with individuals with confirmed pertussis, diphtheria, or tetanus disease in the past 30 days * History of allergy to vaccines or vaccine components, severe side effects to vaccines such as allergy, urticaria, respiratory distress, angioneurotic edema * Those with a history of epilepsy, convulsions, convulsions, cerebral palsy, or a history of mental illness or family history; or other progressive neurological disorders * Have been diagnosed with a congenital or acquired immunodeficiency, HIV infection, lymphoma, leukemia, systemic lupus erythematosus (SLE), juvenile rheumatoid arthritis (JRA), or other autoimmune disease * Any condition resulting in absence of spleen, defective spleen function * Known or suspected acute disease or serious chronic disease (including: serious respiratory disease, serious cardiovascular disease, liver and kidney disease, serious skin disease, malignant tumor, etc.); or in the acute phase of chronic disease * Physician-diagnosed coagulation abnormalities (e.g., clotting factor deficiency, coagulopathy, platelet abnormalities) or significant bruising or clotting disorders * Have had immunosuppressive or modifying agents, cytotoxic continuous treatment for more than 10 days in the past 6 months (except inhaled and topical steroids) * Received blood products (except hepatitis B immunoglobulin) within 3 months prior to receiving the experimental vaccine * Received another investigational drug or investigational vaccine within 1 month prior to receiving the experimental vaccine * Plan to participate or are participating in any other drug clinical studies * Received a live attenuated vaccine within 14 days prior to receiving the experimental vaccine, or received another vaccine within 7 days * Those with fever before vaccination, axillary body temperature \>37.0°C * Any other factors that, in the judgment of the investigator, make participation in the clinical trial inappropriate * 1-20 articles for the first dose exclusion criteria * Those who had a severe allergic reaction after the previous dose of vaccine * Persons with serious adverse reactions causally related to the previous dose of vaccination * Newly discovered or newly occurred after the first vaccination that do not meet the first dose inclusion criteria or meet the first dose exclusion criteria will be determined by the investigator whether to continue to participate in the study * Other reasons for exclusion as perceived by the researcher * 22-25 for the 2nd, 3rd, 4th agent exclusion criteria