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Dissecting the Cellular and Molecular Atlas of Rheumatoid Arthritis in Sustained Remission to Identify Pathways Maintaining Remission and Triggering Flares
Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Summary
The FLARE-RA study will have the following research objectives: A) To establish the cellular and molecular atlas of remission RA achieved with different therapeutics aimed to identify (i) cell clusters/pathways driving disease flare or maintaining remission and (ii) provide an evidence base for developing ML tools for predicting flares. B) To test the performance of a ML-derived algorithm on longitudinal remission RA cohort in a biopsy-driven study. C) To dissect the cellular and molecular mechanisms of remission maintenance and joint flares.
Key Details
Gender
All
Age Range
18 Years - 80 Years
Study Type
OBSERVATIONAL
Enrollment
130
Start Date
2023-07-11
Completion Date
2026-05-10
Last Updated
2023-07-21
Healthy Volunteers
Not specified
Conditions
Interventions
Tapering and/or discontinuation of treatment based on AI-guidance
After synovial tissue biopsy, pharmacological treatment (cDMARDs or bDMARDs) are tapered first and then bDMARDs and/or cDMARDs are discontinued based on AI-guidance
No tapering and/or discontinuation of treatment based on AI-guidance
Ongoing therapeutic are not changed (tapered or discontinued) after synovial biopsy performance based on AI-guidance
Tapering and/or discontinuation of treatment based on standard of care
After synovial tissue biopsy, pharmacological treatment (cDMARDs or bDMARDs) are tapered first and then bDMARDs and/or cDMARDs are discontinued based on standard of care
No tapering and/or discontinuation of treatment based on standard of care
Ongoing therapeutic are not changed (tapered or discontinued) after synovial biopsy performance based on standard of care
Locations (4)
Division of Rheumatology
Rome, Italy
Hospital Clinic and Fundació Clinic per la Recerca Biomèdica
Barcelona, Spain
Research into Inflammatory Arthritis Centre Versus Arthritis (RACE)
Glasgow, United Kingdom
Newcastle University
Newcastle upon Tyne, United Kingdom