Clinical Research Directory

Main Inclusion Criteria: 1. Provision of signed informed consent prior to any study-specific procedures. 2. Male or female of non-childbearing potential patients age ≥40 and \<85 years. 3. Documented diagnosis of symptomatic heart failure (NYHA class II-IV) at enrollment, and a medical history of typical symptoms/signs of heart failure ≥6 weeks before enrollment with at least intermittent need for diuretic treatment. 4. Ejection fraction ≥45% (determined by echocardiography at site laboratory) 5. Increased intraventricular wall thickness (≥11 mm for female and ≥12 mm for male patients by echocardiography at site laboratory) 6. NT-proBNP \> 300 pg/ml (sinus rhythm); \>900 pg/ml (atrial fibrillation at time of screening/inclusion or documented with the last 6 months) 7. BMI between 22 kg/m² and 45 kg/m². Main Exclusion Criteria: 1. Hemoglobin A1C (A1C) ≥10.5% 2. eGFR \<35 mL/min/1.73m² 3. Systolic blood pressure (BP) \<90 mmHg on 2 consecutive measurements at 5-minute intervals, at Screening. 4. Systolic BP≥180 mmHg on 2 consecutive measurements at 5-minute intervals, at Screening. 5. Planned coronary revascularization, ablation of atrial flutter/fibrillation and valve repair/replacement. 6. Stroke or transient ischemic attack (TIA) within 12 weeks prior to enrolment.