Clinical Research Directory
Browse clinical research sites, groups, and studies.
Albumin Catabolic Rate Measured by a Stable Isotope
Sponsor: Ake Norberg
Summary
The goal of this physiological study is to compare albumin catabolic rate measured by a stable isotope labeled amino acid in healthy volunteers and in patients with liver disease. At steady state synthesis and catabolism or degradation are equal. The primary questions it aims to answer are: * Is albumin catabolic rate lower in patients with liver disease? * Is albumin catabolic rate measured by stable isotopes in volunteers like historical controls measured by radio-iodinated albumin at the investigator's laboratory or elsewhere? Subjects will be given an oral dose of the deuterium labeled amino acid phenylalanine that will be incorporated by the liver in newly synthetized albumin molecules, and blood samples will be taken over 12 weeks to determine the catabolic rate of albumin.
Key Details
Gender
All
Age Range
40 Years - Any
Study Type
INTERVENTIONAL
Enrollment
24
Start Date
2023-08-28
Completion Date
2028-12-31
Last Updated
2023-07-25
Healthy Volunteers
Yes
Conditions
Interventions
stable isotopes
The tracer 2H5-phenylalanine is an essential amino acid labeled with deuterium that is a stable isotope, i.e. no radiation is emitted, but the tracer can still be assessed by a combination of gas chromatography and mass spectrometry. The tracer has no measurable effects, but are used for assessment of human physiology.
Locations (1)
Karolinska Institutet
Stockholm, Sweden