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Cadonilimab Combination With Chemotherapy With or Without AK117 in Resectable Gastric or Gastroesophageal Junction Adenocarcinoma
Sponsor: Akeso
Summary
This trial is a Phase II study. All patients are resectable Gastric or Gastroesophageal Junction Adenocarcinoma, Eastern Cooperative Oncology Group (ECOG) performance status 0-1.The purpose of this study is to evaluate the efficacy and safety of cadonilimab combined with chemotherapy with or without AK117 neoadjuvantin treatment of resectable Gastric or Gastroesophageal Junction Adenocarcinoma.
Official title: Phase II Clinical Study of Cadonilimab Combination With Chemotherapy With or Without the Anti-CD47 Antibody AK117 Neoadjuvant/Adjuvant Therapy for Resectable Gastric or Gastroesophageal Junction Adenocarcinoma
Key Details
Gender
All
Age Range
18 Years - 75 Years
Study Type
INTERVENTIONAL
Enrollment
90
Start Date
2023-11-13
Completion Date
2027-11-30
Last Updated
2023-11-18
Healthy Volunteers
No
Interventions
Cadonilimab
IV infusion,Specified dose on specified days
AK117
IV infusion,Specified dose on specified days
Oxaliplatin
IV infusion,Specified dose on specified days
Tegafur-gimeracil-oteracil potassium
Oral,Specified dose on specified days
Docetaxel
IV infusion,Specified dose on specified days
5-Fluorouracil
IV infusion,Specified dose on specified days
Locations (1)
Tianjin Provincial Tumor Hospital
Tianjin, China