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NOT YET RECRUITING
NCT05962021
PHASE2

Neoadjuvant Toripalimab for Non-squamous NSCLC With EGFR Mutation

Sponsor: Peking University People's Hospital

View on ClinicalTrials.gov

Summary

This study was designed to investigate the efficacy and safety of neoadjuvant Toripalimab (anti-PD1) plus chemotherapy for patients with resectable II-IIIB non-squamous NSCLC harboring EGFR mutation, and to explore the potential predictive and prognostic biomarkers, aiming to provide more abundant evidences for the preoperative treatment decision of non-squamous NSCLC patients.

Official title: Neoadjuvant Toripalimab Plus Chemotherapy for Resectable Stage II-IIIB Non-squamous Non-small Cell Lung Cancer With EGFR Mutation: a Multicentre, Multi-cohort, Exploratory Study.

Key Details

Gender

All

Age Range

17 Years - 70 Years

Study Type

INTERVENTIONAL

Enrollment

126

Start Date

2023-08-01

Completion Date

2026-06-30

Last Updated

2023-08-01

Healthy Volunteers

No

Interventions

DRUG

Toripalimab plus Chemotherapy

Therapy was administered on a 21-day regimen for 3 cycles, with Toripalimab (240mg, d1), carboplatin (AUC=5, d1) + pemetrexed (500 mg/m2, d1) for patients with lung adenocarcinoma and carboplatin (AUC=5, d1) + albumin-bound paclitaxel (260 mg/m2, d1) for patients with other subtypes.