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Sleep-specific DBS Therapy in Parkinson's Disease
Sponsor: University of Minnesota
Summary
Sleep-wake disturbances are a major factor associated with reduced quality of life of individuals with Parkinson's disease (PD), a progressive neurological disorder affecting millions of people in the U.S and worldwide. The brain mechanisms underlying these sleep disorders, and the effects of therapeutic interventions such as deep brain stimulation on sleep-related neuronal activity and sleep behavior, are not well understood. Results from this study will provide a better understanding of the brain circuitry involved in disordered sleep in PD and inform the development of targeted therapeutic interventions to treat sleep disorders in people with neurodegenerative disease.
Key Details
Gender
All
Age Range
21 Years - Any
Study Type
INTERVENTIONAL
Enrollment
64
Start Date
2023-06-22
Completion Date
2027-08-01
Last Updated
2026-03-03
Healthy Volunteers
No
Interventions
Clinically optimized deep brain stimulation
Participants will have DBS implanted as standard-of-care. We will be examining the effects of their regular clinical stimulation settings versus no stimulation.
Locations (1)
University Of Minnesota
Minneapolis, Minnesota, United States