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The Fourth Left Atrial Appendage Occlusion Study
Sponsor: Hamilton Health Sciences Corporation
Summary
LAAOS-4 aims to determine if catheter-based endovascular left atrial appendage occlusion prevents ischemic stroke or systemic embolism in participants with atrial fibrillation, who remain at high risk of stroke, despite receiving ongoing treatment with oral anticoagulation.
Official title: The Fourth Left Atrial Appendage Occlusion Study (LAAOS-4)
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
4000
Start Date
2023-11-30
Completion Date
2029-12-01
Last Updated
2026-03-12
Healthy Volunteers
No
Interventions
WATCHMAN device
Participants will undergo endovascular left atrial appendage occlusion with the WATCHMAN device
Locations (127)
Affinity Hospital dba Grandview Medical Center
Birmingham, Alabama, United States
Arrhythmia Research Group
Jonesboro, Arkansas, United States
Memorial Health Services
Fountain Valley, California, United States
Loma Linda University Health
Loma Linda, California, United States
Southern California Permanente Medical Group
Pasadena, California, United States
Sutter Valley Hospitals dba Sutter Institute for Medical Research
Sacramento, California, United States
JFK Medical Center Limited Partnership d/b/a HCA Florida JFK Hospital
Atlantis, Florida, United States
St. Vincent's Health System
Jacksonville, Florida, United States
Largo Medical Center, Inc. d/b/a HCA Florida Largo Medical Center
Largo, Florida, United States
The University of South Florida
Tampa, Florida, United States
Emory University
Atlanta, Georgia, United States
St Luke's Regional Medical Center, Ltd
Boise, Idaho, United States
Kootenai Health Inc.
Coeur d'Alene, Idaho, United States
Northwestern University
Evanston, Illinois, United States
Cardiovascular Medicine, PLLC and Unity Point Trinity Rock Island
Rock Island, Illinois, United States
Community Health Network Inc.
Indianapolis, Indiana, United States
MercyOne Iowa Heart Center
West Des Moines, Iowa, United States
University of Kansas Medical Center Research Institute, Inc.
Kansas City, Kansas, United States
Babtist Health Lexington
Lexington, Kentucky, United States
Ochsner Clinic Foundation
New Orleans, Louisiana, United States
University of Maryland Baltimore
Baltimore, Maryland, United States
Lahey Clinic Inc.
Burlington, Massachusetts, United States
University of Michigan
Ann Arbor, Michigan, United States
Henry Ford Health System
Detroit, Michigan, United States
Henry Ford Health System
Detroit, Michigan, United States
Mayo Clinic
Rochester, Minnesota, United States
Hackensack University Medical Center
Hackensack, New Jersey, United States
The Feinstein Institutes for Medical Research
Manhasset, New York, United States
Cornell University for and on behalf of its Joan & Sanford I. Weill Medical College and The New York Presbyterian Hospital
New York, New York, United States
NYU Grossman School of Medicine
New York, New York, United States
Mission Hospital HCA
Asheville, North Carolina, United States
Aultman Hospital
Canton, Ohio, United States
TriHealth Inc.
Cincinnati, Ohio, United States
University of Cincinnati
Cincinnati, Ohio, United States
Cleveland Clinic
Cleveland, Ohio, United States
Saint Francis Hospital
Tulsa, Oklahoma, United States
The Pennsylvania State University and The Milton S. Hershey Medical Center
Hershey, Pennsylvania, United States
The Trustees of the University of Pennsylvania
Philadelphia, Pennsylvania, United States
University of Pittsburgh Medical Center (UPMC) Presbyterian Heart and Vascular Institute
Pittsburgh, Pennsylvania, United States
Rhode Island Hospital
Providence, Rhode Island, United States
Glanecare, Inc. d/b/a HCA Florida Brandon Hospital
Brentwood, Tennessee, United States
Texas Cardiac Arrhythmia Research Foundation
Austin, Texas, United States
Baylor Research Institute
Dallas, Texas, United States
Heart Rhythm Associates
The Woodlands, Texas, United States
CHRISTUS Northeast Texas Health System
Tyler, Texas, United States
The Rector and Visitors of the University of Virginia
Charlottesville, Virginia, United States
CommonSpirit Health Research Institute
Tacoma, Washington, United States
The Medical College of Wisconsin
Milwaukee, Wisconsin, United States
Imeldaziekenhuis
Bonheiden, Antwerpen, Belgium
AZORG vzw and Hartcentrum Aalst
Aalst, East-Flanders, Belgium
ASBL CHU Helora - Hôpital de La Louvière - site Jolimont
La Louvière, Hainaut, Belgium
CHR de la Citadelle
Liège, Liège, Belgium
AZ Glorieux
Ronse, Oost-Vlaanderen, Belgium
AZ Sint Jan Brugge AV
Bruges, West-Vlaanderen, Belgium
AZ Delta VZW
Roeselare, West-Vlaanderen, Belgium
Universitair Ziekenhuis Brussel
Brussels, Belgium
University of Calgary
Calgary, Alberta, Canada
Vancouver Coastal Health Authority
Vancouver, British Columbia, Canada
St. Boniface Hospital Inc.
Winnipeg, Manitoba, Canada
Circulate Cardiac & Vascular Centre (CCVC)
Burlington, Ontario, Canada
Cambridge Cardiac Care Inc.
Cambridge, Ontario, Canada
Hamilton Health Sciences Corp
Hamilton, Ontario, Canada
Research St. Joseph's - Hamilton
Hamilton, Ontario, Canada
Waterloo Wellington Cardiovascular Research Institute (WWCRI)
Kitchener, Ontario, Canada
Lawson Health Research Institute
London, Ontario, Canada
Southlake Regional Health Centre
Newmarket, Ontario, Canada
Partners in Advanced Cardiac Evaluation (PACE)
Newmarket, Ontario, Canada
Ottawa Heart Institute Research Corp
Ottawa, Ontario, Canada
Niagara Health System - Niagara Falls
St. Catharines, Ontario, Canada
Niagara Health Systems - St. Catharines
St. Catharines, Ontario, Canada
Sunnybrook Health Sciences Center
Toronto, Ontario, Canada
Lawrence Park Cardiology
Toronto, Ontario, Canada
Unity Health Toronto
Toronto, Ontario, Canada
Institut de Cardiologie de Montreal (ICM)
Montreal, Quebec, Canada
Centre hospitalier de l'Université de Montréal
Montreal, Quebec, Canada
Institut universitaire de cardiologie et de pneumologie de Québec-Université Laval
Québec, Quebec, Canada
Centre intégré universitaire de santé et de services sociaux de l'Estrie - Centre hospitalier universitaire de Sherbrooke (CIUSSS de l'Estrie - CHUS)
Sherbrooke, Quebec, Canada
Prairie Valscular Research Inc. (PVRI)
Regina, Saskatchewan, Canada
Saskatchewan Health Authority
Saskatoon, Saskatchewan, Canada
Region Hospital Viborg
Viborg, Central Jutland, Denmark
Aarhus University Hospital (AUH)
Aarhus, Region Midt, Denmark
Esbjerg & Grindsted Hospital - University Hospital of Southern Denmark
Esbjerg, Region Syddanmark, Denmark
Rigshospitalet (RH)
Copenhagen, Denmark
North Denmark Regional Hospital
Hjørring, Denmark
Odense Universitets Hospital
Odense C, Denmark
Infirmerie Protestante de Lyon
Caluire-et-Cuire, Auvergne-Rhône-Alpes, France
CHU Saint Etienne
Saint-Etienne, Auvergne-Rhône-Alpes, France
Centre Hospitalier Régional Universitaire de Tours
Tours, Centre-Val de Loire, France
Clinique Pasteur
Toulouse, Occitanie, France
SCP des Médecins Cardiologues
Toulouse, Occitanie, France
L'Assistance Publique-Hôpitaux de Marseille
Marseille, Provence-Alpes-Côte d'Azur Region, France
Hôpital Pitie Salpétrière
Paris, France
Institut Médico-chirurgical Montsouris
Paris, France
Hôpital Bichat
Paris, France
European Georges Pompidou Hospital
Paris, France
Hospital Prive Jacques Cartier
Massy, Île-de-France Region, France
Centre Cardiologique due Nord
Saint-Denis, Île-de-France Region, France
Städtisches Klinikum Karsruhe gGmbH
Karlsruhe, Baden-Wurttemberg, Germany
Kardiovaskulaeres Zentrum Darmstadt
Darmstadt, Hesse, Germany
CVC Rhein-Main GmbH
Frankfurt am Main, Hesse, Germany
MVZ CCB Frankfurt und Main-Taunus GbR
Frankfurt am Main, Hesse, Germany
Johann Wolfgang Goethe Universität Franfurt - Universitätsklinikum Franfurt
Frankfurt am Main, Hesse, Germany
Krankenhausbetriebsgesellschaft Bad Oeynhausen mbH
Bad Oeynhausen, North Rhine-Westphalia, Germany
Westpfalz-Klinikum GmbH
Kaiserslautern, Rhineland-Palatinate, Germany
Herzzentrum Leipzig GmbH
Leipzig, Saxony, Germany
Universitätsklinikum Schleswig - Holstein
Lübeck, Schleswig-Holstein, Germany
Katholisches Krankenhaus "St. Johann Nepomuk"
Erfurt, Thuringia, Germany
Charité Universitätsmedizin Berlin
Berlin, Germany
Charité - Universitätsmedizin Berlin
Berlin, Germany
Asklepios Kliniken Hamburg GmbH
Hamburg, Germany
Asklepios Kliniken Hamburg GmbH
Hamburg, Germany
Universitätsklinikum Hamburg-Eppendorf (UKE)
Hamburg, Germany
Universitätsklinikum Heidelberg
Heidelberg, Germany
Fondazione Poliambulanza Istituto Ospedaliero
Brescia, Italy
Stichting Catharina Ziekenhuis
Eindhoven, North Brabant, Netherlands
American Heart of Poland SA
Ustroń, Poland
Hospital Álvaro Cunqueiro
Vigo, Pontevedra, Spain
University General Hospital Dr. Balmis
Alicante, Spain
Complejo Asistencial Universitario de León
León, Spain
Universitario La Luz - Grupo Quirónsalud
Madrid, Spain
Hospital Clínico Universitario de Valladolid
Valladolid, Spain
University Hospitals of Leicester NHS Trust
Leicester, Leicestershire, United Kingdom
Oxford University Hospitals NHS Foundation Trust
Oxford, Oxfordshire, United Kingdom
University Hospitals Coventry and Warwickshire
Coventry, West Midlands, United Kingdom
University Hospitals Sussex NHS Trust
Worthing, West Sussex, United Kingdom
Liverpool Heart and Chest Hospital NHS Foundation Trust
Liverpool, United Kingdom
University Hospital Southampton NHS Foundation Trust
Southampton, United Kingdom