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Pilot Feasibility Study of Fecal Microbiota Transplant for the Treatment of Small Intestinal Bacterial Overgrowth
Sponsor: McMaster Children's Hospital
Summary
The objective of the study is to assess feasibility, and clinical efficacy of a novel Fecal Microbiota Transplantation protocol for the treatment of pediatric small intestinal bacterial overgrowth (SIBO).
Key Details
Gender
All
Age Range
3 Years - 18 Years
Study Type
INTERVENTIONAL
Enrollment
20
Start Date
2024-03-11
Completion Date
2026-12-31
Last Updated
2025-08-21
Healthy Volunteers
No
Conditions
Interventions
Fecal Microbiota Transplant
Participants will receive approximately 50 grams of human stool/150mL (approximately 107 microbes/mL of suspension) in saline, prepared as per standard collection, preparation, and screening protocols for FMT infusion developed by our institutional stool bank in accordance with recognized standards. Fecal microbiota transplant infused via existing enteral feeding tube or upper elective endoscopy (with infusion into the duodenum) x1.
Locations (2)
McMaster Children's Hospital
Hamilton, Ontario, Canada
Hospital for Sick Children (SickKids)
Toronto, Ontario, Canada