Clinical Research Directory

Inclusion criteria (RAPID receiver) * 18 years ≤ age ≤ 68 years * Indication of LT for HCC validated in multidisciplinary meeting * AFP score ≤ 2 (15) * Body mass index \< 30 kg/m2 * MELD score ≤ 15, without access to prioritization * PET CT-choline and PET CT-FDG without sign of extra-hepatic localizaton * Patient having been informed and able to give written consent to participate in the RAPID-HCC study * Validation of the patient's inclusion in the RAPID-HCC protocol by the scientific committee Exclusion criteria * History of, liver transplant, surgical or radiological portocaval anastomosis * History of major abdominal surgery (including hepatectomy) * History of abdominal radiotherapy (extrahepatic) * History of acute/chronic pancreatitis * Expected combined transplant * HCC located 1 cm away from the transection line required by the first stage hepatectomy * Portal or arterial thrombosis * patient with a pre-graft hepatic venous pressure gradient ≥ 20mmHg * Ascites (clinical or radiological) less than 5 years ago * Hepatitis C viral load + * Acute or chronic hepatitis B (not cured) * HIV + serology * Severe comorbidities, in particular severe cardiovascular or respiratory or renal pathology (at the discretion of the medical-surgical team) * Patient on anticoagulant treatment * Patient who has received (or is due to receive) preoperative treatment with radioembolization on the right side, hepatectomy or radiotherapy near the hilum * Patient who received (or should receive) preoperative treatment with anti-tyrosine kinase (TKI) less than three months ago * Patients receiving or having received immunotherapy Donor selection criteria: * Brain-dead donor (no living donor) * 18 years ≤ age ≤ 65 years * Hepatic, vascular and biliary anatomy compatible with performing a split. Analysis entrusted to the team that will carry out the split, and based on the scanner of the donor (to be available on the Biomedicine Agency website) * Biological and hepatic assessment compatible with the realization of a split, in particular transaminases \< 4 times the normal * Graft not assigned to a protocol requiring machine infusion. * Serology: anti-HBc negative, anti-HCV negative