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Perioperative Oral Decontamination and ImmunoNuTrition (POINT) in Elderly
Sponsor: Peking Union Medical College Hospital
Summary
The goal of this multicenter randomized controlled trial is to explore the efficacy of perioperative oral decontamination and immunonutrition supplement to prevent postoperative pulmonary complications in elderly patients(≥65 years) receiving elective non-cardiac operations. Participants will be either given immunonutrition supplement versus routine nutrition advice, and oral chlorhexidine decontamination versus routine oral care randomly. The two interventions will be compared with control groups separately regarding postoperative pulmonary complications and other outcomes.
Official title: Perioperative Oral Decontamination and ImmunoNuTrition (POINT) on Postoperative Pulmonary Complications in Elderly: a Multicenter Randomized Controlled Trial
Key Details
Gender
All
Age Range
65 Years - Any
Study Type
INTERVENTIONAL
Enrollment
592
Start Date
2023-08-23
Completion Date
2025-09-01
Last Updated
2025-01-28
Healthy Volunteers
No
Interventions
immunonutrition supplement of ORAL IMPACT™
For intervention group, patients will take immunonutrition supplement after recruitment until the day before surgery.
oral chlorhexidine decontamination
For intervention group, patients will use 0.12% chlorhexidine for oral rinse twice daily from the day before surgery until 3 days after surgery.
Locations (2)
The Second Hospital of Hebei Medical University
Shijiazhuang, Hebei, China
Peking Union Medical College Hospital
Beijing, China