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Blood Lipid Responses to Diet Macronutrients
Sponsor: University of Oxford
Summary
The macronutrient composition of a diet (proportions of carbohydrates, fats and proteins) strongly influences the way the body stores and utilises substrates (e.g., fats and sugars), which in turn influences the risk of developing cardiometabolic diseases (e.g., coronary artery disease or insulin resistance). The optimal dietary composition to lower the risk of cardiometabolic disease is unknown. In a randomized, parallel design, this study will investigate how the overconsumption of carbohydrates and fats affects blood lipid responses and liver metabolism in adults free from metabolic disease. By genotyping participants, the interaction between macronutrient content and an individual's genes on blood lipid responses and liver metabolism will be examined.
Official title: Investigating Blood Lipid Responses to Dietary Macronutrient Content
Key Details
Gender
All
Age Range
18 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
60
Start Date
2023-02-15
Completion Date
2028-01
Last Updated
2026-05-11
Healthy Volunteers
Yes
Conditions
Interventions
Diet
Eucaloric diet enriched in either carbohydrates or fat (both contributing to 65% total energy intake)
Locations (2)
Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford
Oxford, United Kingdom
Oxford Centre for Diabetes, Endocrinology and Metabolism
Oxford, United Kingdom