Clinical Research Directory

Inclusion Criteria: 1. Subjects participate voluntarily and sign informed consent. 2. Age ≥ 18 and ≤ 80 years old, male or female. 3. Histological or cytological or clinical diagnosis of HCC 4. Barcelona Clinic Liver Cancer stage C. BCLC stage B, not suitable for radical surgery and/or local treatment. 5. No prior systemic therapy for HCC. 6. Child-Pugh ≤7 , no history of hepatic encephalopathy. Exclusion Criteria: 1. Histologically or cytologically documented fibrolamellar hepatocellular carcinoma, sarcoma-like hepatocellular carcinoma, cholangiocarcinoma, etc. 2. History of malignancy other than HCC within 5 years prior to the start of study treatment. 3. History of liver transplantation, or planned to receive liver transplantation. 4. Moderate or severe ascites with clinical symptoms that require drainage, uncontrolled or moderate or severe pleural and pericardical effusion. 5. Has known active central nervous system (CNS) metastases and/or carcinomatous meningitis. 6. Involvement of both the main portal vein and the left and right branches by portal vein tumor thrombus, or of both the main trunk and the superior mesenteric vein concurrently, or of inferior vena cava.