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Exploring the Effects of Varying Fat:Carbohydrate Diet Permutations on Gastric Emptying and Metabolic Status Using Human Postprandial Model
Sponsor: Malaysia Palm Oil Board
Summary
The aim of this clinical trial is to investigate the effects of the meals moderated by fat and carbohydrate (CHO) quality along with varying macronutrient distribution (CHO: fat) on gut physiology and metabolic outcomes using the human postprandial model with healthy subjects. The main question\[s\] it aims to answer are: 1. How does meal composition with different polyunsaturated/saturated (P/S) ratio, glycemic index and macronutrient quantity affect lipemia and glycemia? 2. How does meal composition with different P/S ratio, Glycemic index and macronutrient quantity affect gastric emptying?
Key Details
Gender
All
Age Range
21 Years - 40 Years
Study Type
INTERVENTIONAL
Enrollment
12
Start Date
2022-05-21
Completion Date
2024-12-24
Last Updated
2026-05-26
Healthy Volunteers
Yes
Interventions
FIJA
A 5-hour postprandial feeding intervention with 1-weeks washout in between. Blood samples will be collected at 0 hour (baseline) and up to 5 hours after consumption of test meal.
F1JB
A 5-hour postprandial feeding intervention with 1-weeks washout in between. Blood samples will be collected at 0 hour (baseline) and up to 5 hours after consumption of test meal.
F2JA
A 5-hour postprandial feeding intervention with 1-weeks washout in between. Blood samples will be collected at 0 hour (baseline) and up to 5 hours after consumption of test meal.
F2JB
A 5-hour postprandial feeding intervention with 1-weeks washout in between. MRI scan and blood samples will be collected at 0 hour (baseline) and up to 5 hours after consumption of test meal.
F3JA
A 5-hour postprandial feeding intervention with 1-weeks washout in between. MRI scan and blood samples will be collected at 0 hour (baseline) and up to 5 hours after consumption of test meal.
F3JB
A 5-hour postprandial feeding intervention with 1-weeks washout in between. MRI scan and blood samples will be collected at 0 hour (baseline) and up to 5 hours after the consumption of test meal.
F4JA
A 5-hour postprandial feeding intervention with 1-weeks washout in between. MRI scan and blood samples will be collected at 0 hour (baseline) and up to 5 hours after consumption of test meal.
F4JB
A 5-hour postprandial feeding intervention with 1-weeks washout in between. MRI scan and blood samples will be collected at 0 hour (baseline) and up to 5 hours after consumption of test meal.
F1PA
A 5-hour postprandial feeding intervention with 1-weeks washout in between. MRI scan and blood samples will be collected at 0 hour (baseline) and up to 5 hours after consumption of test meal.
F1PB
A 5-hour postprandial feeding intervention with 1-weeks washout in between. MRI scan and blood samples will be collected at 0 hour (baseline) and up to 5 hours after consumption of test meal.
F2PA
A 5-hour postprandial feeding intervention with 1-weeks washout in between. MRI scan and blood samples will be collected at 0 hour (baseline) and up to 5 hours after consumption of test meal.
F2PB
A 5-hour postprandial feeding intervention with 1-weeks washout in between. MRI scan and blood samples will be collected at 0 hour (baseline) and up to 5 hours after consumption of test meal.
F3PA
A 5-hour postprandial feeding intervention with 1-weeks washout in between. MRI scan and blood samples will be collected at 0 hour (baseline) and up to 5 hours after consumption of test meal.
F3PB
A 5-hour postprandial feeding intervention with 1-weeks washout in between. MRI scan and blood samples will be collected at 0 hour (baseline) and up to 5 hours after consumption of test meal.
F4PA
A 5-hour postprandial feeding intervention with 1-weeks washout in between. MRI scan and blood samples will be collected at 0 hour (baseline) and up to 5 hours after consumption of test meal.
F4PB
A 5-hour postprandial feeding intervention with 1-weeks washout in between. MRI scan and blood samples will be collected at 0 hour (baseline) and up to 5 hours after consumption of test meal.
HGI PLAIN RICE
A 5-hour postprandial feeding intervention with 1-weeks washout in between. MRI scan and blood samples will be collected at 0 hour (baseline) and up to 5 hours after consumption of test meal.
LGI PLAIN RICE
A 5-hour postprandial feeding intervention with 1-weeks washout in between. MRI scan and blood samples will be collected at 0 hour (baseline) and up to 5 hours after consumption of test meal.
Locations (3)
Department of Medicine, Faculty of Medicine, Hospital Cancelor Tuanku Mukhriz, Universiti Kebangsaan Malaysia
Kuala Lumpur, Kuala Lumpur, Malaysia
Malaysian Palm Oil Board
Kajang, Selangor, Malaysia
School of Biosciences, Faculty of Health and Medical Sciences, Taylor's University
Subang Jaya, Selangor, Malaysia