Clinical Research Directory
Browse clinical research sites, groups, and studies.
Circadian Rhythm and Other Factors in Memory Clinic Patients
Sponsor: Assistance Publique - Hôpitaux de Paris
Summary
The CIRCAME study is a bicentric study of patients from 2 memory clinics in Paris. The main objective is to identify circadian rhythm components and other individual risk factors (sociodemographic, behavioral, and health related factors) associated with the diagnosis of subtypes (AD, Lewy bodies, vascular, frontotemporal dementia) and stages (cognitively healthy, mild cognitive impairment, clinical dementia) of dementia, independent of known risk factors (sociodemographic and genetic) and assess the relevance of use of these factors in primary care for screen of dementia including subtypes and stages. A secondary objective is to determine factors associated with progression of the disease, in terms of cognitive decline and limitations in activities of daily living, as well as progression to dementia among cognitively healthy controls and patients with mild cognitive impairment, up to 15 years after the inclusion period.
Official title: Circadian Rhythm and Other Individual Factors Among Memory Clinic Patients
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
1200
Start Date
2024-03-06
Completion Date
2042-03
Last Updated
2026-02-19
Healthy Volunteers
Yes
Conditions
Interventions
Questionnaire
The questionnaire includes information on socio-demographics (age, sex, education, occupation, marital status), behavioural (smoking, alcohol consumption, social functioning), and health-related factors (morbidities, treatment, sleep disturbance, eye diseases, frailty, falls).
Clinical examination
This includes earing test, cognitive tests (mini-mental status examination, MemScreen), body mass index, waist circumference, blood pressure and blood tests (biomarkers of Alzheimer's disease, neurodegeneration, and other dementias).
Accelerometer port
Participants will be wearing an accelerometer for 9 days.
Eye examination
Eye fundus photo, OCT and OCT-A exams
Ear Examination
Otoscopic examination, Wideband tympanometry, Pure-tone and speech audiometry (in quiet and in noise), Auditory evoked potentials, Electroencephalogram with auditory stimulation
Locations (2)
Centre de neurologie Cognitive / CMRR
Paris, France, France
Hôpital de Jour Gériatrique et consultation mémoire
Paris, France, France