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ENROLLING BY INVITATION
NCT05979441
PHASE3

A Study to Assess the Long-term Safety and Efficacy of a Subcutaneous Formulation of Efgartigimod in Adults With Active Idiopathic Inflammatory Myopathy

Sponsor: argenx

View on ClinicalTrials.gov

Summary

The main purpose of this study is to measure the long-term safety and tolerability of efgartigimod PH20 SC in adult participants with Idiopathic Inflammatory Myopathy (IIM) who previously participated in ARGX-113-2007. The study consists of a treatment period where participants will receive efgartigimod PH20 SC for up to 51 months. The treatment period will be followed by a treatment-free safety follow-up period of 56 days.

Official title: A Phase 3, Single-Arm, Multicenter, Open-label Extension of Study ARGX-113-2007 to Investigate the Long-term Safety, Tolerability, and Efficacy of Efgartigimod PH20 SC in Participants Aged 18 Years and Older With Active Idiopathic Inflammatory Myopathy

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

240

Start Date

2023-09-12

Completion Date

2028-09

Last Updated

2026-03-10

Healthy Volunteers

No

Interventions

BIOLOGICAL

Efgartigimod PH20 SC

Subcutaneous injection of Efgartigimod PH20 given by vials or prefilled syringe (PFS)

Locations (80)

Neuromuscular Clinical and Research Center - Neurology

Phoenix, Arizona, United States

Attune Health Research, Inc

Beverly Hills, California, United States

UCI Health - ALS and Neuromuscular Center - Neurology

Orange, California, United States

UCSF Health - ALS and Neurodegenerative Disease Center - Dermatology

San Francisco, California, United States

Yale Cancer Center-Yale University School Of Medicine

New Haven, Connecticut, United States

UF Health - Rheumatology Medical Specialties Medical Plaza

Gainesville, Florida, United States

Mayo Clinic - Florida - Neurology

Jacksonville, Florida, United States

Emory Healthcare - Emory Clinic - Rheumatology

Atlanta, Georgia, United States

Northwestern Medicine - Northwestern Memorial Hospital

Chicago, Illinois, United States

Northwell Health Physician Partners Rheumatology

Great Neck, New York, United States

University of North Carolina (UNC) School of Medicine

Chapel Hill, North Carolina, United States

The Ohio State University

Columbus, Ohio, United States

Oregon Health and Science University

Portland, Oregon, United States

University of Pittsburgh Medical Center

Pittsburgh, Pennsylvania, United States

Austin Neuromuscular Center (National Neuromuscular Research Institute, PLLC)

Austin, Texas, United States

Nerve And Muscle Center Of Texas

Houston, Texas, United States

Framingham Centro Medico

La Plata, Argentina

Centro Dermatologico Schejtman

San Miguel, Argentina

Centro Medico Privado de Reumatologia

San Miguel de Tucumán, Argentina

Tirol Kliniken - A.o. Landeskrankenhaus Innsbruck - Neurology

Innsbruck, Austria

AZ Sint-Lucas - Campus Sint-Lucas - Neurology

Ghent, Belgium

Universitair Ziekenhuis Leuven Gasthuisberg Campus

Leuven, Belgium

Medical Centre Artmed

Plovdiv, Bulgaria

Multiprofile hospital for active treatment Kaspela EOOD

Plovdiv, Bulgaria

Peking Union Medical College Hospital

Beijing, China

Sichuan Provincial Academy of Medical Sciences and Sichuan Provincial People's Hospital

Chengdu, China

Shanghai Jiao Tong University School of Medicine - Renji Hospital - Shanghai Institute of Digestive Disease (SIDD)

Shanghai, China

Cyprus Institute of Neurology and Genetics

Nicosia, Cyprus

Revmatologicky Ustav

Prague, Czechia

Copenhagen University Hospital-Rigshospitalet University Hospital

Copenhagen, Denmark

Reference Center Neuro-Muscular Diseases - CHU Paris Group Hospitalier La Pitie Salpetriere-Charles Foix

Paris, France

Aversi Clinic

Tbilisi, Georgia

LLC MediClub Georgia

Tbilisi, Georgia

New Hospitals

Tbilisi, Georgia

The First Medical Center

Tbilisi, Georgia

Charite Universitaetsmedizin Berlin - Campus Charite Mitte (CCM) - Rheumatology

Berlin, Germany

Universitaetsklinikum Hamburg-Eppendorf

Hamburg, Germany

Rheumazentrum Ruhrgebiet

Herne, Germany

Universitatsmedizin Mannheim GmbH

Mannheim, Germany

Universitaetsklinikum Tuebingen (UKT)

Tübingen, Germany

Klinikum der Universitaet Ulm

Ulm, Germany

National and Kapodistrian University of Athens - School of Health Sciences - Faculty of Medicine

Athens, Greece

National and Kapodistrian University of Athens - Eginition Hospital

Athens, Greece

ATTIKON University General Hospital - Neurology

Athens, Greece

University College Dublin (UCD) - St. Vincent's University Hospital (SVUH)

Dublin, Ireland

Azienda Ospedaliero Universitaria Consorziale Policlinico

Bari, Italy

Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) - Ospedale San Raffaele Hospital

Milan, Italy

Azienda Ospedaliero Universitaria Pisana - Ospedale Santa Chiara - Rheumatology

Pisa, Italy

Ospedale Sant'Andrea Hospital

Roma, Italy

Fondazione Policlinico Universitario Agostino Gemelli - Neurology

Roma, Italy

Azienda sanitaria universitaria Friuli Centrale - ASUFC

Udine, Italy

Juntendo University Hospital

Bunkyō City, Japan

The University of Tokyo Hospital

Bunkyō City, Japan

Japan Community Healthcare Organization Chukyo Hospital

Nagoya, Japan

Wakayama Medical University Hospital

Wakayama, Japan

Santaros University Clinic

Vilnius, Lithuania

Hospital Angeles Clinica Londres

Mexico City, Mexico

Amsterdam UMC Research BV

Amsterdam, Netherlands

Clinica San Juan de Dios - sede Arequipa - Rheumatology

Arequipa, Peru

Instituto Peruano Del Hueso Y La Articulacion Sac-Privado-Lima,Centro De Investigacion Iphar

Lima, Peru

Investigaciones Clinicas S.A.C.

Lima, Peru

USK-WAM Centralny Szpital Weteranow - Szpital Kniniczny ul. Zeromskiego 113 - Rheumatology

Lodz, Poland

Centrum Wsparcia Badan Klinicznych Pomorskiego Uniwersytetu Medycznego w Szczecinie (CWBK PUM) - Rheumatology

Szczecin, Poland

Centro Hospitalar do Porto - Hospital Santo Antonio

Porto, Portugal

Clinical Center of Serbia

Belgrade, Serbia

Institute of Rheumatology

Belgrade, Serbia

Seoul National University Hospital

Seoul, South Korea

Hospital de la Santa Creu i Sant Pau

Barcelona, Spain

Hospital Universitario 12 de Octubre

Madrid, Spain

Hospital Universitari i Politecnic La Fe de Valencia - Neurology

Valencia, Spain

Karolinska Universitestssjukhus Solna

Solna, Sweden

Chung Shan Medical University Hospital

Taichung, Taiwan

King Chulalongkorn Memorial Hospital - Neurology

Bangkok, Thailand

Phramongkutklao Hospital

Bangkok, Thailand

Ramathibodi hospital

Bangkok, Thailand

Siriraj Hospital, Mahidol University of Internal medicine

Bangkok, Thailand

Faculty Of Medicine, Khon Kaen University

Khon Kaen, Thailand

Aintree University Hospital - Liverpool University Hospitals NHS Foundation Trust

Liverpool, United Kingdom

The Royal Free Hospital

London, United Kingdom

Northern Care Allicance NHS Foundation Trust - Salford Royal - Rheumatology

Salford, United Kingdom