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Using Gut Microbial Gbu Gene Testing to Estimate Host TMAO Production Capacity
Sponsor: National Taiwan University Hospital
Summary
The risk of cardiovascular diseases from red meat consumption varies among individuals due to variations in gut microbiota. L-carnitine in red meat can be converted to TMAO in the body by certain bacteria. Not everyone experiences a significant increase in TMAO levels after consuming carnitine. Gut microbiota differences are observed between high and low TMAO producers. The presence of the gbu gene in gut microbiota is linked to TMAO production. This clinical research aims to determine if the gbu gene can predict TMAO levels after dietary carnitine intake.
Official title: Evaluation of Microbial-derived TMAO Production From Carnitine Intake by Testing Fecal Gbu Gene
Key Details
Gender
All
Age Range
18 Years - 70 Years
Study Type
INTERVENTIONAL
Enrollment
230
Start Date
2023-07-24
Completion Date
2026-07-30
Last Updated
2026-01-12
Healthy Volunteers
Yes
Interventions
L-carnitine
Participants are required to take a capsule containing 500mg L-carnitine/day continuous for 7-10 days.
Locations (1)
National Taiwan University Hospital
Taipei, Taiwan