Clinical Research Directory

Inclusion Criteria: 1. Newly diagnosed patients, aged 18 to 75 years; 2. Pathologically confirmed rectal adenocarcinoma; 3. Distance of the lower margin of the rectal tumor lesion from the anal margin \<15cm; 4. High-resolution MRI indicates low-risk locally advanced rectal cancer: T1-3bN1-2 or T3aN0 or T3bN0; no involvement of the anal sphincter; negative mesorectal fascia (MRF) status; negative extramural vascular invasion (EMVI); no cancer nodules; 5. Exclusion of patients with non-local recurrence or distant metastases; 6. Absence of synchronous colorectal multiple primary cancers; 7. Adequate physical condition to tolerate surgery and neoadjuvant chemotherapy, including cardiac, pulmonary, hepatic, and renal functions; 8. The study physician assessed no difficulty in sphincter preservation; 9. patients and their families will be willing to participate in this study and provide written informed consent. Exclusion Criteria: 1. Patients with concurrent other malignancies or a history of malignant tumors in the past; 2. Patients with intestinal obstruction, intestinal perforation, intestinal bleeding, or other conditions requiring emergency surgery; 3. Patients with tumor invasion into the external sphincter or levator ani muscles, or involvement of adjacent organs necessitating combined organ resection; 4. Patients with poor anal function or fecal incontinence before surgery; 5. Patients with a history of inflammatory bowel disease or familial adenomatous polyposis; 6. Patients recently diagnosed with other malignancies; 7. Patients with ASA grade ≥ IV and/or ECOG performance status score \> 2; 8. Patients with severe liver or kidney dysfunction, significant cardiopulmonary impairment, coagulation disorders, or those with extreme underlying conditions unable to tolerate surgery; 9. Patients with a history of severe mental illness; 10. Pregnant or lactating women; 11. Patients with uncontrolled infections before surgery; 12. Patients with other clinical or laboratory conditions, as determined by the investigator, that render them unsuitable for participation in this trial.