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Brain Outcomes With Lifestyle Change in Down Syndrome
Sponsor: University of Kansas Medical Center
Summary
The goal of this study is to determine if weight loss or changes in dietary intake can help prevent of delay adults with Down syndrome from developing Alzheimer's Disease Adults with Down syndrome without dementia will be randomized to either a weight loss group or a general health education control group. The weight loss group will be asked to follow a reduced energy diet, attend monthly education sessions delivered remotely and self-monitor diet and body weight using commercially available web-based applications. The control group will be asked to attend remotely delivered monthly education sessions on general health education topics. All participants will come to the University of Kansas Medical Center, 3 times across 12 months for a blood draw, cognitive testing, a MRI, assessment of height and weight, and assessment of diet intake.
Official title: The Impact of Weight Loss on Alzheimer's Disease Risk in Adults With Down Syndrome
Key Details
Gender
All
Age Range
18 Years - 64 Years
Study Type
INTERVENTIONAL
Enrollment
81
Start Date
2024-10-22
Completion Date
2027-09-30
Last Updated
2026-03-11
Healthy Volunteers
No
Conditions
Interventions
Diet
A reduced calorie diet which uses frozen meals purchased at the store and focuses on increasing fruits and vegetables associated with brain health.
Health Education
Monthly health education sessions delivered remotely.
Locations (1)
University of Kansas Medical Center
Kansas City, Kansas, United States