Clinical Research Directory

Inclusion Criteria: * Meet the DSM-5 diagnostic criteria for schizophrenia or schizoaffective disorder; * Age18-50, right-handed, Han nationality; * Score of at least 1 item from N1 to N7 in PANSS is ≥4 (moderate or above); * Be in a stable condition, received second-generation antipsychotics for at least 4 weeks or more; * Written informed consent; Exclusion Criteria: * Current or past neurological illness, severe physical diseases, substance abuse or alcohol dependence, mental retardation, pregnant or lactation; * Uncooperative or risky patients with high excitement, stupor, disorder of words and deeds, negative suicide, etc.; * History of MECT or other physical therapy within 6 months; * History of epilepsy, or epileptic waves on the baseline EEG; * Ruled out share antiepileptic drugs, carbamazepine, valproic acid salt) or larger doses of benzodiazepines drugs (\> 10 mg/day, diazepam clonazepam 2 mg/day, 1 mg/day, alprazolam lorazepam 2 mg/day, midazolam 10 mg/day, 20 mg/day, Mr Shah diazepam triazolam 0.5 mg/day), avoid the use of chlorine drug, (in principle, to avoid the use of antiepileptic drugs and clonazepam;Other antipsychotic drugs, if necessary, remain unchanged during the course of treatment; * Contraindications to TUS and MRI are present.