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Interrogating the Pathophysiological Mechanisms of Constipation in Patients With Systemic Sclerosis
Sponsor: The University of Texas Health Science Center, Houston
Summary
The purpose of this study is to determine whether transcutaneous electrical acustimulation (TEA) alters systemic sclerosis (SSc)-related colonic and anorectal physiology by enhancing autonomic nervous system (ANS) function. The study will examine the effects of TEA on slow colonic transit (SCT) and rectal hyposensitivity (RH), to examine whether TEA improves autonomic dysfunction and modulates inflammatory pathways.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
60
Start Date
2024-02-17
Completion Date
2029-09-01
Last Updated
2025-06-26
Healthy Volunteers
No
Interventions
Transcutaneous Electrical Acustimulation (TEA)
TEA will then be administrated for 1 hour twice daily for a period of 4 weeks
Sham-TEA
Sham TEA will then be administrated for 1 hour twice daily for a period of 4 weeks
Locations (1)
The University of Texas Health Science Center at Houston
Houston, Texas, United States