Clinical Research Directory

Inclusion Criteria: * Adults \>40 years of age * Pain at the thumb base brought on by direct pressure (grind test) and with movement * Pain resistant to previous conservative management (including over the counter medications (ibuprofen/acetaminophen), icing, splinting/braces, or topical analgesics) * Radiological observation indicative of arthritis based on the Eaton-Littler classification system (stages 1 through 4) * Patient understands the protocol and signed the informed consent * Patient is covered by health insurance Exclusion Criteria: * • Known allergy to either of the treatment products * Patient's analgesic treatment regimen or other modalities of managing symptoms/pain associated with their hand pathology was modified within four weeks before trial inclusion * Symptomatic Scaphoid-trapezial arthritis present * Localized or systemic infection * Previous thumb surgery on study thumb * Previous thumb injury on study thumb * Patient with inflammatory arthritis (e.g., rheumatoid arthritis, psoriatic arthritis) * Severe and/or uncontrolled hypertension * De Quervain tendinopathy present * History of injection to the trapeziometacarpal joint on study thumb within the previous 6 weeks * Uncontrolled diabetes * Pregnant or lactating females. Female participants of childbearing potential must have a negative pregnancy test before the injection. Women without childbearing potential (ie., surgically sterile with hysterectomy and/or bilateral oophorectomy and/or bilateral salpingectomy OR ≥ 12 months of amenorrhea and at least 50 years of age) are eligible to participate without completing a pregnancy test. * Immunodeficient patients * Patients that are currently using nicotine products, or who have quit in the last 12 months * Patients under guardianship, curatorship, or are otherwise not self-sufficient * Patients participating in another clinical research trial which interferes with this study protocol or outcomes * Patients unable to follow the protocol in the investigators' judgement.