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RECRUITING
NCT05993390
NA

Pharmacological Reversal of Neuromuscular Blockade in Critically Ill Patients

Sponsor: Seoul National University Hospital

View on ClinicalTrials.gov

Summary

The goal of this clinical trial is to compare the effect of use of reversal agents for neuromuscular blockade in critically ill patients on time for neurological assessment after endotracheal intubation The main questions it aims to answer are: * The use of reversal agents for neuromuscular blockade after endotracheal intubation may reduce the time for neurological assessment. * The types of reversal agents for neuromuscular blockade may affect the time for neurological assessment. Participants will receive different reversal agents or no medications based on the assigned groups. Thirty minutes after intubation using rocuronium, medication is administered, and the time of initial confirmation of eye opening and movement is recorded. Researchers will compare 3 groups (sugammadex, neostigmine and control(no medication) to see the difference of time for neurological assessment after endotracheal intubation.

Official title: Effect of Neuromuscular Reversal Agents on Time for Neurological Assessment After Endotracheal Intubation in Critically Ill Patients

Key Details

Gender

All

Age Range

19 Years - 90 Years

Study Type

INTERVENTIONAL

Enrollment

30

Start Date

2024-01-11

Completion Date

2025-08-30

Last Updated

2024-06-24

Healthy Volunteers

No

Interventions

DRUG

Sugammadex

Intravenous administration of sugammadex 2mg/kg.

DRUG

Neostigmine

Intravenous administration of neostigmine 0.05mg/kg with glycopyrrolate 0.01mg/kg

Locations (1)

Seoul National University Hospital

Seoul, Jongno-gu, South Korea