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Pharmacological Reversal of Neuromuscular Blockade in Critically Ill Patients
Sponsor: Seoul National University Hospital
Summary
The goal of this clinical trial is to compare the effect of use of reversal agents for neuromuscular blockade in critically ill patients on time for neurological assessment after endotracheal intubation The main questions it aims to answer are: * The use of reversal agents for neuromuscular blockade after endotracheal intubation may reduce the time for neurological assessment. * The types of reversal agents for neuromuscular blockade may affect the time for neurological assessment. Participants will receive different reversal agents or no medications based on the assigned groups. Thirty minutes after intubation using rocuronium, medication is administered, and the time of initial confirmation of eye opening and movement is recorded. Researchers will compare 3 groups (sugammadex, neostigmine and control(no medication) to see the difference of time for neurological assessment after endotracheal intubation.
Official title: Effect of Neuromuscular Reversal Agents on Time for Neurological Assessment After Endotracheal Intubation in Critically Ill Patients
Key Details
Gender
All
Age Range
19 Years - 90 Years
Study Type
INTERVENTIONAL
Enrollment
30
Start Date
2024-01-11
Completion Date
2025-08-30
Last Updated
2024-06-24
Healthy Volunteers
No
Interventions
Sugammadex
Intravenous administration of sugammadex 2mg/kg.
Neostigmine
Intravenous administration of neostigmine 0.05mg/kg with glycopyrrolate 0.01mg/kg
Locations (1)
Seoul National University Hospital
Seoul, Jongno-gu, South Korea