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Investigating the Neural Mechanisms of Repetitive Brain Stimulation With Invasive and Noninvasive Electrophysiology in Humans
Sponsor: Stanford University
Summary
Transcranial magnetic stimulation (TMS) is an effective treatment for depression, but clinical outcome is suboptimal, partially because investigators are missing biologically-grounded brain markers which show that TMS is modifying activity at the intended target in the brain. The goal of this proposal is to characterize the key markers of the brain's response to repeated doses of TMS with high resolution using invasive brain recordings in humans, and relate these brain markers to noninvasive recordings. These markers will improve the understanding of TMS and can be used to optimize and enhance clinical efficacy for depression and other psychiatric disorders.
Key Details
Gender
All
Age Range
18 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
49
Start Date
2023-09-01
Completion Date
2027-12-01
Last Updated
2026-03-12
Healthy Volunteers
No
Conditions
Interventions
Intracranial electrodes
Intracranial electrodes will be used for the delivery of invasive brain stimulation.
TMS
TMS will be used for the delivery of noninvasive brain stimulation both before and after implantation electrode surgery.
Locations (1)
Stanford University
Stanford, California, United States