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Effect of Repetitive TMS on Executive Function in Alcohol Use Disorder
Sponsor: Universidad Nacional Autonoma de Mexico
Summary
Alcohol Use Disorder (AUD) is a major public health problem that affects the physical, social, family, and mental integrity of the sufferer. Behavioral self-regulation is compromised in AUD, and a benefit has been reported with the application of repetitive transcranial magnetic stimulation and emotional self-regulation. The aim of this study is to investigate the efficacy of high-frequency rTMS to improve executive functions in patients in abstinence from AUD.
Official title: Effect of Repetitive Transcranial Magnetic Stimulation on the Executive Function in Alcohol Use Disorder
Key Details
Gender
All
Age Range
25 Years - 59 Years
Study Type
INTERVENTIONAL
Enrollment
44
Start Date
2024-03-16
Completion Date
2026-11-01
Last Updated
2025-02-10
Healthy Volunteers
No
Conditions
Interventions
Repetitive Transcranial Magnetic Stimulation
The investigators will use a Magstim Rapid 2 stimulator, Airfilled coil (AFC), 8 shape (magnetic field of 0.8 Teslas, 3Kg, pulse 0.5 ms) Each patient will receive high frequency 10 Hz stimulation at 100% of motor threshold over the dorsolateral prefrontal cortex (DLPFC) at 1500 pulses per session with 30 trains of 5 seconds and 0.5 ms stimuli and an inter-train distance of 15 seconds. In 2 daily sessions 4 days a week for 4 weeks.
Repetitive Transcranial Magnetic Stimulation (Sham)
The investigators will use a Magstim Rapid 2 stimulator, Airfilled coil (AFC), 8 shape (magnetic field of 0.8 Teslas, 3Kg, pulse 0.5 ms) Each patient will receive consistent treatment in 2 sessions a day for 20 consecutive business days for 4 weeks. The coil will be placed on the vertex target location.
Locations (1)
Unidad de Resonancia Magnética
Querétaro City, Querétaro, Mexico