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Optimizing Early Nutrition Support in Severe Stroke-2
Sponsor: Wen Jiang-3
Summary
Post stroke pneumonia (PSP) is one of the common early complications of stroke. Post-stroke infections, in general, are associated with less favorable neurologic outcomes. Aspiration is one of the most feared complications of enteral nutrition and can lead to the occurrence of pneumonia. Severe stroke patients are at high risk for aspiration due to some factors such as the reduced level of consciousness, inability to protect the airway and so on. The purpose of this study is to explore the ideal nutrition support strategy for patient with acute severe stroke to help reduce the incidence of PSP and improve the prognosis.
Official title: Trophic Enteral Feeding Combined With Supplemental Parenteral Nutrition Treatment in Patients With Severe Stroke (OPENS-2): a Multicentre, Prospective, Randomised, Open-label, Blinded-endpoint Trial
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
546
Start Date
2023-12-20
Completion Date
2026-10-31
Last Updated
2026-03-19
Healthy Volunteers
No
Conditions
Interventions
Trophic enteral feeding combined with supplemental parenteral nutrition
The caloric goal of the first day is one-third of caloric requirements, the second day is half of caloric requirements, the third day is 70-100% and sustained for 1 week. Patients will receive the trophic enteral feeding with a caloric target of 500kcal/d (20-35ml/h), and the remaining calories are supplemented by parenteral nutrition. Protein requirements are calculated at 1.2 to 1.5 g per kilogram of body weight per day.
Full enteral feeding
The caloric goal of the first day is one-third of caloric requirements, the second day is half of caloric requirements, the third day is 70-100% and sustained for 1 week. Protein requirements are calculated at 1.2 to 1.5 g per kilogram of body weight per day. Enteral nutrition is given through nasogastric tube or nasointestinal tube.
Locations (30)
Chongqing University Three Gorges Hospital
Chongqing, Chongqing Municipality, China
Daping Hospital, The Third Military Medical University
Chongqing, Chongqing Municipality, China
Gansu Provincal Central Hospital
Lanzhou, Gansu, China
Nanfang Hospital, Southern Medical University
Guangzhou, Guangdong, China
The Second Affiliated Hospital of Guangzhou University of Chinese Medicine
Guangzhou, Guangdong, China
The Affiliated Hospital of Guizhou Medical University
Guiyang, Guizhou, China
First Affiliated Hospital of Zhengzhou University
Zhengzhou, Henan, China
Tongji Hospital
Wuhan, Hubei, China
The First Hospital of Changsha City
Changsha, Hunan, China
The Second Affiliated Hospital of Nanchang University
Nanchang, Jiangxi, China
General Hospital of Ningxia Medical University
Yinchuan, Ningxia, China
Shaanxi Second Provincal People's Hospital
Xi'an, Shaanxi, China
Tangdu Hospital
Xi'an, Shaanxi, China
The first affiliated hospital of Xi'an Jiaotong University
Xi'an, Shaanxi, China
Xi'an Central Hospital
Xi'an, Shaanxi, China
Department of Neurology, Xijing Hospital
Xi'an, Shaanxi, China
Shannxi Provincal People's Hospital
Xi'an, Shaanxi, China
The First Affiliated Hospital of Xi'an Medical University
Xi'an, Shaanxi, China
Xi'an Gaoxin Hospital
Xi'an, Shaanxi, China
Xi'an No.3 Hospital
Xi'an, Shaanxi, China
Xianyang Hospital, Yan'an University
Xianyang, Shaanxi, China
The First People's Hospital of Xianyang
Xianyang, Shaanxi, China
Yulin No.1 Hospital
Yulin, Shaanxi, China
Yulin No.2 Hospital
Yulin, Shaanxi, China
Qilu Hospital of Shangdong University
Jinan, Shandong, China
The PLA 960 Hospital
Jinan, Shandong, China
The Second Hospital of Shandong University
Jinan, Shandong, China
Liaocheng People's Hospital
Liaocheng, Shandong, China
People's Hospital of Xinjiang Uygur Autonomous Region
Ürümqi, Xinjiang, China
The Second Affiliated Hospital of Xinjiang Medical University
Ürümqi, Xinjiang, China