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Georgia Memory Net Anti-Amyloid Monoclonal Antibody Registry
Sponsor: Emory University
Summary
The purpose of this registry is to compile information on patients who are receiving FDA-approved anti-amyloid mAbs in the course of their clinic visits in the Emory Cognitive Neurology Clinic and in Georgia Memory Net Memory Assessment Clinics.
Official title: Georgia Memory Net Center for Medicare and Medicaid Services Registry for Anti-Amyloid Monoclonal Antibody Coverage With Evidence Development
Key Details
Gender
All
Age Range
50 Years - 90 Years
Study Type
OBSERVATIONAL
Enrollment
735
Start Date
2025-03-06
Completion Date
2028-07
Last Updated
2026-03-11
Healthy Volunteers
No
Conditions
Interventions
Anti-amyloid Monoclonal Antibodies (mAbs)
Infusions of lecanemab occur every 2-weeks as indicated in the FDA labeling. After 18 months of treatment, an amyloid positron emission tomography (PET) scan with FDA-approved radiotracer is performed to confirm clearance of amyloid pathology. It is anticipated that most individuals treated with lecanemab for 18 months will no longer have positive amyloid PET scans. In those instances where persistent amyloid pathology is seen, every 2-week treatment with lecanemab will be continued for an additional 6 months with repeat amyloid PET scan until amyloid clearance is achieved. If an individual has progressed to moderate or severe stages of AD dementia during the initial 18 months of treatment and amyloid PET shows failure to clear amyloid pathology, treatment will be terminated. Dosing frequency after 18 months (or after amyloid clearance) remains unclear and will need to be determined with additional evidence development.
Standard of Care
The standard of care, other than treatment with anti-amyloid mAbs, provided at the study clinics.
Locations (8)
Georgia Memory Net Memory Assessment Clinic - Albany
Albany, Georgia, United States
Georgia Memory Net Memory Assessment Clinic - Atlanta
Atlanta, Georgia, United States
Emory Clinic
Atlanta, Georgia, United States
Georgia Memory Net Memory Assessment Clinic - Augusta
Augusta, Georgia, United States
Georgia Memory Net Memory Assessment Clinic - Gainesville
Gainesville, Georgia, United States
Georgia Memory Net Memory Assessment Clinic - Macon
Macon, Georgia, United States
Georgia Memory Net Memory Assessment Clinic - Savannah
Savannah, Georgia, United States
Georgia Memory Net Memory Assessment Clinic - Vidalia
Vidalia, Georgia, United States