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Studying the Health of Asians to Advance Knowledge, Treatments, and Interventions for Depression
Sponsor: University of Texas Southwestern Medical Center
Summary
SHAKTI (from the Sanskrit word for "power") is a 5-year natural history, longitudinal, prospective study of a cohort of 6,000 participants that will help uncover the socio-demographic, lifestyle, clinical, psychological, and neurobiological factors that contribute to antidepressant treatment response (remission, recurrence, relapse and individual outcomes in depressive disorders) and resilience. As this is an exploratory study, we will assess a comprehensive panel of carefully selected participant specific parameters - socio-demographic (age, sex, gender, race, ethnicity, economic); life habits (physical activity, substance use); clinical (medical history, anxious depression, early life trauma), biological (biomarkers in blood, saliva, urine, stool), behavioral (cognitive, emotional), neurophysiological (EEG), and neuroimaging (magnetic resonance imaging; MRI) with the goal of developing the most robust predictive models of depression treatment response and of outcomes.
Official title: Studying the Health of Asians to Advance Knowledge, Treatments, and Interventions for Depression (SHAKTI)
Key Details
Gender
All
Age Range
10 Years - Any
Study Type
OBSERVATIONAL
Enrollment
6000
Start Date
2024-03-01
Completion Date
2035-02
Last Updated
2025-08-21
Healthy Volunteers
Yes
Conditions
Interventions
Observational Study
No Treatment or Intervention Provided
Locations (1)
UT Southwestern Medical Center
Dallas, Texas, United States