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Right Ventricular Dysfunction in Chronic Heart Failure
Sponsor: University of Siena
Summary
The goal of this multi center observational prospective study is to analyze the concordance between the signs and symptoms of RHF and echocardiographic features of RVD in patient with heart failure. The main questions it aims to answer are: 1. to assess the incidence of RVH and RVD in each HF subtypes. 2. to evaluate prognostic impact ( in terms of cardiovascular mortality and HF hospitalization) of different RVD patterns during a mean followup period of 3 years 3. To investigate the incidence of different RV maladaptation ( isolated RV dilatation, isolated Pulmonary hypertension, combined pattern) in each HF groups and the related outcome. Participants will follow by direct check up visit and/or virtual visits every 6 months for a mean follow-up period of 3 years.
Official title: Right Ventricular Dysfunction in Chronic Heart Failure: Clinical Laboratory and Echocardiographic Characteristics
Key Details
Gender
All
Age Range
18 Years - 90 Years
Study Type
OBSERVATIONAL
Enrollment
1000
Start Date
2023-09-01
Completion Date
2026-09-01
Last Updated
2023-08-21
Healthy Volunteers
No
Interventions
Echocardiography
Patients will undergo echocardiographic examination. The ejection fraction will be calculated using Simpson's method. The E/e' ratio will be measured using the Doppler method. E/e' \> 13 will be considered an expression of the increase in LVFP. TAPSE will be measured together with the peak tricuspid regurgitation velocity (TVR). Pulmonary arterial hypertension will be defined as TVR \> 2.8 m/s. Estimation of right atrial pressure (eRAP) will be obtained based on the diameter and inspiratory collapsibility of the inferior vena cava.
Laboratory Test
BNP, NT-proBNP and renal function.
Locations (14)
Centro Cardiologico Monzino
Milan, Milano, Italy
Department of Medicine, Surgery and Dentistry, Università di Salerno
Fisciano, Salerno, Italy
SC Universitaria di Cardiologia - UTIC Policlinico Riuniti Foggia
Foggia, Italy
Department of Clinical and Experimental Medicine, Operativee Unit of Cardiology, University of Messina
Messina, Italy
Ospedale Sant'Agostino Milano
Milan, Italy
Department of Translational Medical Sciences, CIRCET
Naples, Italy
Department of Translational Medical Sciences, Federico II University, CIRCET
Naples, Italy
Heart Failure Unit, Department of Cardiology, AORN dei Colli-Monaldi
Naples, Italy
Fondazione IRCCS Policlinico San Matteo - Pavia UOC Cardiologia 1
Pavia, Italy
S. Maria della Misericordia Hospital
Perugia, Italy
SC Cardiologia, Azienda Ospedaliera Ospedale San Carlo Potenza
Potenza, Italy
Cardiology, Department of Clinica, Internal, Anesthesiology and Cardiovascular Scienses, Sapienza.
Roma, Italy
Cardiology, Department of Clinica, Internal, Anesthesiology and Cardiovascular Scienses.
Roma, Italy
Unità di Malattie Cardiovascolari, Dipartimento Cardio-Toraco-Vascolare AOUS, Università degli Studi, Siena.
Siena, Italy