Clinical Research Directory

Inclusion Criteria: 1. Meet the clinically definite or clinically probable PD according to the MDS 2015 version. 2. Chinese Han population (three generations), age greater than or equal to 50 years old, less than or equal to 80 years old, male or female. 3. Hoehn-Yahr stages 1-4. 4. The dose of levodopa drug therapy was stable three weeks before enrollment and during the follow-up period. 5. Right-handed. 6. The patient signed a written informed consent. Exclusion Criteria: 1. Any form of Parkinsonism other than primary PD. 2. Those who have received neurosurgical intervention or stereotaxic brain surgery for PD, or have previously received TMS treatment. 3. Cognitive dysfunction (MMSE ≤ 24 points) or those who cannot cooperate with the scale score. 4. Persons with mental disabilities. 5. Pregnant women. 6. There are contraindications for rTMS treatment. 7. There are contraindications for MRI examination. 8. Baseline PSG suggests other sleep disorders such as moderate to severe OSAS; BMI\>=30. 9. Patients who are addicted to alcohol, taking SSRIs, TCAs, sedative hypnotics, histamine antagonists and other drugs and food that may affect NREM and REM sleep structure. 10. Those who are unwilling to participate in the study or unable to sign the informed consent form; and other circumstances that the researcher considers inappropriate to participate in the study. \-