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CSF Metabolomics and Glymphatic Function in Patients Receiving VP- Shunt Surgery.
Sponsor: Chang Gung Memorial Hospital
Summary
In this randomized control study, the investigators intended to evaluate the influence of different anesthetics on postoperative cognitive dysfunction, neuroinflammation, CSF metabolomics, and glymphatic function in patients with normal pressure hydrocephalus for VP shunt surgery. The investigators assume that the use of dexmedetomidine infusion and proper anesthsia depth during general anesthesia, in addition to multi-model analgesia, might be helpful to enhance glymphatic function, reduce neuroinflammation, and decrease postoperative cognitive dysfunction.
Official title: The Application of Anesthesia Depth Monitoring on Post-operative Cognitive Dysfunction for Patients With Hydrocephalus Receiving Ventricular-peritoneal Shunt Surgery and Associated Change in CSF Metabolomics and Glymphatic Function.
Key Details
Gender
All
Age Range
60 Years - Any
Study Type
INTERVENTIONAL
Enrollment
48
Start Date
2023-07-01
Completion Date
2026-06-30
Last Updated
2023-08-22
Healthy Volunteers
No
Conditions
Interventions
Dexmedetomidine
dexmedetomidine infusion
anesthesia depth monitoring
intraoperative anesthesia depth monitoring to keep BIS 40-60
Locations (1)
Linkou Chang Gung Memorial Hospital
Taoyuan District, Taiwan