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Maternal Brain Imaging in Opioid Use Disorder
Sponsor: Indiana University
Summary
This research study aims to learn more about opioid use disorder (OUD) during pregnancy and how outcomes for pregnant women and their newborns can be improved. During pregnancy, people with OUD are prescribed medication-assisted therapy (MAT). The investigators are interested to know how the medication is broken down by the body during pregnancy and how effective it is. The investigators also want to learn if this medication and OUD have any effect on the different parts of the brain when compared to mothers without OUD.
Key Details
Gender
FEMALE
Age Range
18 Years - 100 Years
Study Type
OBSERVATIONAL
Enrollment
40
Start Date
2023-08-15
Completion Date
2026-07-31
Last Updated
2026-01-08
Healthy Volunteers
Yes
Conditions
Interventions
Buprenorphine
Pregnant mother must be taking Buprenorphine
Maternal Brain MRI
Maternal Brain MRI obtained between 24-32 week gestation
Blood Samples
During the MRI visit blood samples will be drawn: one hour prior to MRI, immediately before MRI, and one hour post MRI to test for Buprenorphine levels.
Questionnaires
Participants will answer questionnaires about their medical history, pregnancy, and substance use.
Locations (1)
Riley Hospital for Children
Indianapolis, Indiana, United States