Clinical Research Directory

Inclusion Criteria: * Patients who may potentially benefit from treatment with esmethadone (REL-1017) as determined by the treating physician. * Have undergone appropriate standard treatments without success and in the opinion of the treating physician no comparable or satisfactory alternative treatment is available to treat the disease or condition. * Are ineligible or unable to participate in any ongoing clinical study of the investigational product. * Condition for which, in the opinion of the treating physician, there is sufficient evidence of a potential benefit from the use of the investigational product, and that potential benefit outweighs the known or anticipated risks. Exclusion Criteria: * History or presence of clinically significant health conditions which in the opinion of the Investigator would negatively impact the safety of the participant. * History of QTc prolongation. * History of allergy or hypersensitivity to methadone or related drugs. * Pregnant or planning to become pregnant. * Breast-feeding or planning to breast-feed.