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RECRUITING
NCT06011876
NA

BioFLO for Respiratory Recovery in SCI

Sponsor: University of Florida

View on ClinicalTrials.gov

Summary

Acute intermittent hypoxia (AIH) involves brief (1 min), repeated episodes (\~15) of breathing low oxygen air to stimulate spinal neuroplasticity. Animal and human studies show that AIH improves motor function after spinal cord injury, particularly with slightly increased carbon dioxide (hypercapnic AIH; AIHH) and task-specific training. Using a double blind cross-over design, the study will test whether AIHH improves breathing more than AIH and whether specific genetic variations are related to individuals' intervention responses.

Official title: Genetic Biomarkers of Intermittent Hypoxia-Induced Respiratory Motor Plasticity in Chronic SCI

Key Details

Gender

All

Age Range

18 Years - 70 Years

Study Type

INTERVENTIONAL

Enrollment

62

Start Date

2023-12-21

Completion Date

2027-09

Last Updated

2025-11-05

Healthy Volunteers

No

Interventions

OTHER

Acute Intermittent Hypoxia (AIH)

AIH (acute intermittent hypoxia) consists of short episodes of low oxygen (9% O2).

OTHER

Acute Intermittent Hypercapnic-Hypoxia (AIHH)

AIHH consists of short episodes of low oxygen (9% O2) and elevated carbon dioxide (4% CO2).

OTHER

Sham AIH

A single session of sham AIH with episodes of normal room air (21% O2).

Locations (1)

Brooks Rehabilitation

Jacksonville, Florida, United States