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BioFLO for Respiratory Recovery in SCI
Sponsor: University of Florida
Summary
Acute intermittent hypoxia (AIH) involves brief (1 min), repeated episodes (\~15) of breathing low oxygen air to stimulate spinal neuroplasticity. Animal and human studies show that AIH improves motor function after spinal cord injury, particularly with slightly increased carbon dioxide (hypercapnic AIH; AIHH) and task-specific training. Using a double blind cross-over design, the study will test whether AIHH improves breathing more than AIH and whether specific genetic variations are related to individuals' intervention responses.
Official title: Genetic Biomarkers of Intermittent Hypoxia-Induced Respiratory Motor Plasticity in Chronic SCI
Key Details
Gender
All
Age Range
18 Years - 70 Years
Study Type
INTERVENTIONAL
Enrollment
62
Start Date
2023-12-21
Completion Date
2027-09
Last Updated
2025-11-05
Healthy Volunteers
No
Conditions
Interventions
Acute Intermittent Hypoxia (AIH)
AIH (acute intermittent hypoxia) consists of short episodes of low oxygen (9% O2).
Acute Intermittent Hypercapnic-Hypoxia (AIHH)
AIHH consists of short episodes of low oxygen (9% O2) and elevated carbon dioxide (4% CO2).
Sham AIH
A single session of sham AIH with episodes of normal room air (21% O2).
Locations (1)
Brooks Rehabilitation
Jacksonville, Florida, United States