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Personalized Real-Time DBS and PD Mechanisms
Sponsor: David Escobar
Summary
A prospective cohort of patients scheduled to undergo deep brain stimulation (DBS) implantation surgery for the treatment of Parkinson's disease as per standard of care will be invited to participate in this study. This mechanistic study is aimed at better understanding the role of basal ganglia beta band (11-35 Hz) oscillations and resonance in the manifestation of Parkinson's disease (PD) motor signs using closed-loop electrical neurostimulation, levodopa medication, and computational modeling. The ultimate goal of this study is to inform the development of closed-loop neuromodulation technology that can be programmed and adjusted in real time based on patient-specific neural activity.
Official title: Identifying Circuit Dynamics Underlying Motor Dysfunction in Parkinson's Disease Using Real-Time Neural Control
Key Details
Gender
All
Age Range
18 Years - 80 Years
Study Type
INTERVENTIONAL
Enrollment
25
Start Date
2023-08-29
Completion Date
2028-06-30
Last Updated
2025-05-14
Healthy Volunteers
No
Conditions
Interventions
Neurostimulation
Electrical stimulation delivered via deep brain stimulation electrodes based on measurements of brain activity.
Carbidopa 25/Levodopa 100Mg Tab
Anti-parkinsonian medication.
Locations (1)
Cleveland Clinic
Cleveland, Ohio, United States