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Volatile Sedation for Patients With the Acute Respiratory Distress Syndrome
Sponsor: Guy's and St Thomas' NHS Foundation Trust
Summary
This study will investigate how different types of routine sedation may affect patient's breathing whilst on a ventilator in the Intensive Care Unit (ICU). There are different approaches to sedation which may have advantages and disadvantages. During the study patients will receive both intravenous and inhaled volatile sedation (similar to anaesthetic 'gases' used for general anaesthesia) and the drive to breath, breathing efforts and function of the lung will be assessed.
Official title: Effect of Volatile Sedation on Spontaneous Breathing During Mechanical Ventilation for Patients With the Acute Respiratory Distress Syndrome
Key Details
Gender
All
Age Range
17 Years - Any
Study Type
INTERVENTIONAL
Enrollment
20
Start Date
2023-11-01
Completion Date
2027-07-31
Last Updated
2026-06-04
Healthy Volunteers
No
Conditions
Interventions
Propofol
Standard care, propofol sedation - 2 hour periods of observation before and after inhaled volatile sedation
Isoflurane
Inhaled volatile sedation for 6 hours - 2 hours wash in / wash out, followed by 4 hours of observations
Locations (1)
Guy's & St Thomas' NHS Foundation Trust
London, London, United Kingdom