Clinical Research Directory

Inclusion Criteria: * Aged 40-75 years. * Body mass index (BMI) ≥25 kg/m2 * Male, or postmenopausal (at least 1 year post cessation of menses) female * Pre-diabetes based on one or a combination of the following criteria: * Impaired Glucose Tolerance (IGT): plasma glucose values ≥ 7.8 mmol/l and ≤ 11.1 mmol/l 120 minutes after glucose drink consumption during OGTT in screening * ImpairedFastingGlucose(IFG):Fastingplasmaglucose≥6.1mmol/land≤6.9 mmol/l * Insulin Resistance: glucose clearance rate ≤ 360 mL/kg/min, as determined during the OGTT using OGIS120. * HbA1cof5.7-6.4% Exclusion Criteria: * Type 2 diabetes * Patients with active congestive heart failure and and/or severe renal and or liver insufficiency * Uncontrolled hypertension * Any contra-indication for MRI scanning * Alcohol consumption of \>3 servings per day for man and \>2 servings per day for woman * Smoking * Unstable body weight (weight gain or loss \> 5kg in the last 3 months) * Previous enrolment in a clinical study with an investigational product during the last 3 months or as judged by the Investigator which would possibly hamper our study results. * Medication use known to hamper subject's safety during the study procedures. * Subjects who do not want to be informed about unexpected medical findings. * Men: Hb \<8.0 mmol/L, Women: Hb \<7.0 mmol/l * Heavily varying sleep-wake rhythm (i.e. night shift work and travels across time zones). * Significant food allergies/intolerance (seriously hampering study meals) * Blood donation during or within 2 months prior to the study