Clinical Research Directory
Browse clinical research sites, groups, and studies.
Outcomes for Anesthesiologist-Led Care of Analgesic Protocol in Anorectal Surgery
Sponsor: China-Japan Friendship Hospital
Summary
This will be an open, prospective, parallel-group, randomized controlled trial. Patients scheduled for complex anorectal surgery under general anesthesia will be enrolled, and the perioperative analgesia mode led by anesthesiologists will be established. Compared with the perioperative analgesia mode led by surgeons, the efficacy and safety of analgesia, quality of life and satisfaction of patients will be evaluated. This study is aimed at the feasibility and efficiacy of anesthesiologist-led treatment mode in the management of moderate and severe pain in patients after complex anorectal surgery.
Key Details
Gender
All
Age Range
18 Years - 85 Years
Study Type
INTERVENTIONAL
Enrollment
216
Start Date
2024-09-10
Completion Date
2025-10-10
Last Updated
2024-11-13
Healthy Volunteers
No
Conditions
Interventions
Analgesia plan for Anes. Group
For Anes. Group, hydromorphone intravenous pump (PCIA) with 0.04mg/hr and 0.2mg/hr bolus controlled administration. Rescue opioids will be given as sufentanil 5μg/hr, depending on the time of the last intraoperative administration. NSAIDs such as flurbiprofen axetil or ibuprofen will be administered as a complementary treatment option.
Analgesia plan for Surg. Group
For Surg. Group, hydromorphone intravenous pump is set with the same analgesic formula as in Anes. Group. Routine prescriptions for rescue opioids (tramadol) and NSAIDs according to pain level recommended by the pharmacy department will be administered.
Multi-modal analgesia during the surgery
Multi-modal analgesia, including intraoperative long-acting local anesthetics (ropivacaine and methylene blue), perioperative narcotic analgesics, and postoperative laxative and antibiotics. PCIA with the same analgesic formula will be applied in both groups.
Locations (2)
China-Japan Friendship Hospital
Beijing, Beijing Municipality, China
Department of Anesthesiology
Beijing, Beijing Municipality, China