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ACTIVE NOT RECRUITING
NCT06015672
NA

Accelerated TMS for Focal Hand Dystonia

Sponsor: Duke University

View on ClinicalTrials.gov

Summary

This study aims to investigate the impact of accelerated transcranial magnetic stimulation (TMS) on brain function and behavior in patients with focal hand dystonia. Previous research demonstrated that individualized TMS improved dystonic behavior after one session. Building on this, the current study administers four TMS sessions in a day, with assessments conducted in four weeks, twelve weeks, and 20 weeks after each session. The research involves 8 in-person and 6 virtual visits focused on functional MRI brain scans and writing behavior analysis. The potential risk of seizures from TMS is mitigated through careful screening, adhering to safety guidelines. The study's main benefit is enhancing dystonic behavior and deepening the understanding of brain changes caused by TMS in focal hand dystonia, paving the way for further advancements in clinical therapy for this condition.

Official title: Duke Accelerated Transcranial Magnetic Stimulation for Focal Hand Dystonia

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

21

Start Date

2023-12-21

Completion Date

2027-02-05

Last Updated

2026-03-11

Healthy Volunteers

No

Interventions

DEVICE

Transcranial Magnetic Stimulation (TMS)

Participants will have two accelerated transcranial magnetic stimulation (TMS) visits. Each TMS visit will be separated by 5 months. During each TMS visit, they will receive four TMS sessions, each separated by 60 minutes of rest.

Locations (1)

Duke University Health System

Durham, North Carolina, United States