Clinical Research Directory
Browse clinical research sites, groups, and studies.
Purinergic Signaling and the Postmenopausal Heart
Sponsor: Beth Israel Deaconess Medical Center
Summary
There is an increased risk of diastolic heart failure in post menopausal women. Estrogen plays a positive role in regulating molecular pathways in heart remodeling. Such pathways may work through purinergic signaling and its downstream effects on the heart's mitochondrial metabolism and angiogenic response to stress. Loss of estrogen functionality in post menopausal women may account for the increased risk of diastolic heart failure. The investigators will explore said pathways using cardiac tissue obtained from patients undergoing cardiac surgery.
Official title: PGC-1, Purines and the Postmenopausal Heart
Key Details
Gender
All
Age Range
30 Years - 88 Years
Study Type
OBSERVATIONAL
Enrollment
500
Start Date
2019-07-01
Completion Date
2030-06
Last Updated
2026-03-20
Healthy Volunteers
No
Interventions
Gender
Differences between men and women will be observed
Locations (1)
Beth Israel Deaconess Medical Center
Boston, Massachusetts, United States