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Bioactive Lipids & PBMC
Sponsor: Université Catholique de Louvain
Summary
The investigators aim at harvesting PBMC from healthy donors to study the effect of the lipids mediators of interest. After isolation from the blood, PBMC will be activated as largely reported in the literature in the presence or absence of the tested lipids. The effect will be assessed by quantifying the expression of inflammatory markers. The expression of the receptors and enzymes potentially regulating the effects of the studied lipids will also be assessed.
Official title: Investigations on the Role of Bioactive Lipids in the Control of PBMC Activation and Differentiation.
Key Details
Gender
All
Age Range
18 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
100
Start Date
2023-09-01
Completion Date
2030-05
Last Updated
2023-08-30
Healthy Volunteers
Yes
Conditions
Interventions
healthy volunteers blood sampling
One blood sample will be taken from healthy volunteers in order to isolate PBMC and to assess the effect of the lipid of interest on them PBMC will be activated in vitro (e.g. using LPS or PHA) in the presence or absence of the lipid of interest.