Clinical Research Directory

Inclusion Criteria: * Adult (≥18 years), with presumptive pulmonary TB i.e., self-reporting cough ≥2 weeks and ≥1 other symptom typical of pulmonary TB\* * Willing to provide written informed consent * Willing to provide sputum, and other samples (tongue swabs, urine) * Willingness to have a telephonic follow-up call 2-3 months post-enrolment * Documented HIV status and CD4 count within last 6 months, or if unavailable, then willing to undergo testing * fever, night sweats or unintended weight-loss Exclusion Criteria: * Participants currently on anti-TB treatment \* * Any anti-TB treatment or antibiotics not specifically used for TB treatment, but which have anti-TB activity, e.g., fluoroquinolones given for respiratory tract infection within 60 days prior to enrolment * Any tuberculosis preventive therapy (TPT) within 6 months prior to enrolment * Participants who have conditions or circumstances that preclude their participation, based on the judgement of the site investigator * Unable to produce at least 3ml of sputum \* Participants starting anti-TB treatment at the time of enrolment will not be excluded from the study provided that all study specimens are collected before starting the 3rd dose of treatment.