Clinical Research Directory

Inclusion criteria: * Female adult patients with severe osteoarthritis scheduled to have primary total knee arthroplasty * Age 40 or older * 35 kg/m2 and above * Only patients from the PI's clinic will be included. * Women who are still menstruating and are currently on contraceptives and women who are in menopause. Exclusion Criteria: * Patients who have some active local or widespread infection (including secondary or inflammatory osteoarthritis) * medical conditions that put them at risk of complications or death during and after the study would not be eligible for surgery * Patients with previous knee surgery on arthroplasty site will be excluded * Pregnant patients and women who are capable of getting pregnant