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Melanin and Dermal Uptake of Thirdhand Cigarette Smoke
Sponsor: University of California, San Francisco
Summary
This is a pilot study of the effects of dermal melanin on dermal uptake and retention of nicotine. The initial hypothesis is that higher levels of dermal melanin will correlate with lower uptake and longer retention of nicotine in the skin and body.
Key Details
Gender
All
Age Range
18 Years - 50 Years
Study Type
INTERVENTIONAL
Enrollment
60
Start Date
2023-09-01
Completion Date
2026-11
Last Updated
2026-06-16
Healthy Volunteers
Yes
Conditions
Interventions
Wear clothing that has been exposed to cigarette smoke for 3 hours.
Cotton clothing is exposed to smoke from Marlboro Red (hard pack) cigarettes at 1-1.2 mg/m3 repeatedly, until total exposure equals 3 grams total particulate material. When tested after exposure, the clothing typically contained 59.15 +/- 18 µg nicotine and 42 +/- 24 ng NNK per gram. The mass of the clothing varies by size, but the average combination of pants and shirt contains 32 mgs nicotine and 23 µg NNK.
Locations (1)
Zuckerberg San Francisco General Hospital
San Francisco, California, United States